Expression and Prognostic Value of Hcgβ in Digestive Tract Malignancies
نویسنده
چکیده
.....................................................................................................................................7 INTRODUCTION ............................................................................................................................9 REVIEW OF THE LITERATURE................................................................................................10 CHEMISTRY AND BIOLOGY OF CHORIONIC GONADOTROPIN AND ITS SUBUNITS...............................10 BIOLOGICAL FUNCTION OF HCG AND ITS SUBUNITS.......................................................................11 CLINICAL USE OF HCG DETERMINATIONS......................................................................................12 Normal pregnancy.....................................................................................................................12 Pregnancy related disorders......................................................................................................12 Gestational trophoblastic disease and germ cell tumours...........................................................12 EXPRESSION OF FREE β-SUBUNIT OF HUMAN CHORIONIC GONADOTROPIN......................................13 HCGβ in healthy subjects and in benign conditions...................................................................13 HCGβ in malignant diseases .....................................................................................................13 HCGβ in digestive tract malignancies .......................................................................................14 Molecular detection of hCGβ in neoplasms ...............................................................................14 COLORECTAL CANCER...................................................................................................................15 Epidemiology of colorectal cancer ............................................................................................15 Staging of colorectal cancer......................................................................................................15 Diagnosis and treatment of colorectal cancer............................................................................16 Serum tumour markers in colorectal cancer ..............................................................................16 Other prognostic factors in colorectal cancer............................................................................18 GASTRIC CANCER..........................................................................................................................19 Epidemiology of gastric cancer .................................................................................................19 Staging of gastric cancer...........................................................................................................19 Histological types of gastric cancer...........................................................................................20 Diagnosis and treatment of gastric cancer.................................................................................21 Serum tumour markers in gastric cancer ...................................................................................21 Other prognostic factors in gastric cancer.................................................................................21 PANCREATIC CANCER....................................................................................................................22 Epidemiology of pancreatic cancer............................................................................................22 Staging of pancreatic cancer .....................................................................................................22 Diagnosis and treatment of pancreatic cancer ...........................................................................23 Serum tumour markers in pancreatic cancer..............................................................................24 Other prognostic factors in pancreatic cancer ...........................................................................24 AIMS OF THE STUDY..................................................................................................................25 MATERIALS AND METHODS ....................................................................................................26 PATIENTS AND SAMPLES................................................................................................................26 Tissue samples (I)......................................................................................................................26 Serum samples (II-V).................................................................................................................26 METHODS .....................................................................................................................................27 Immunohistochemical staining procedure (I).............................................................................27 Serum Assays (II-V)...................................................................................................................28
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